AOD-9604
Also: hGH fragment 177–191 · Tyr-hGH 177–191
- Status
- Research
- Evidence
- Limited
- Field
Metabolic
1
What it is
A failed obesity drug candidate that reappeared on the peptide market. Fragmenting GH did not deliver GH-like fat loss in adequate trials. Treat current marketing as recycling, not a new discovery.
2
How it works
A modified C-terminal fragment of growth hormone, developed to isolate lipolytic effects without the full GH/IGF-1 growth axis. That was the hypothesis. Clinical obesity development did not succeed.
3
The evidence
Calzada/Metabolic Pharmaceuticals-era trials in obesity did not meet the bar for approval. Some small body-composition and cartilage papers exist. This is not a hidden success story.
4
Sourcing
Not FDA-approved. Previously explored as a drug; not on the US market as a medicine. WADA has listed it. Research-chemical sales persist.
A failed obesity drug candidate, not an approved medicine. Research-chemical sales persist. WADA lists GH fragments. Not a compounding success story.
Same four pathways as the Sourcing guide.
5
Will insurance pay?
None. The development program did not produce a product for a formulary.
6
Grey market
Reappeared as a 'safe GH fragment' in fat-loss stacks. That marketing recycles a failed file.
Strand does not list vendors. See the grey market.
7
Risks
Trial-era safety was generally unremarkable, which is not efficacy. Gray-market injectables reintroduce sterility and identity risk. It should not be assumed 'safer than GH' in unsupervised use.
- Obesity trials did not meet the bar for approval — that is evidence of non-success, not a hidden win.
- Grey-market injectables reintroduce sterility and identity risk.
- Anti-doping listing for tested athletes.
8
Papers
Obesity development
Metabolic Pharmaceuticals-era AOD-9604 trials did not achieve approval.
GH fragments listed among prohibited agents.
Related
- Tesamorelin — Approved
- CJC-1295 — Research